Waaaaaaaaaaaaaaay to early for a 2012 run. Hell, it's even too early for a 2010 mid-term run. That makes no sense. Why resign? None of the candidates of the 2008 election resigned their positions as they were running for office. And if that is her real reason for resigning from office now this will come back to bite her big time.
I'm with you guys, something fishy is going on here. We'll soon find out.