Take more difficult but important classes like Wills and Trusts, Tax, any upper level legal writing courses that may be required, etc. Save interesting classes that you will enjoy for your 3d year.
One could also argue that taking classes you will get the best grades in will benefit you more early on than as a 3L. I have two friends that got pwn3d during OCI this fall but after cleaning up on first semester grades clinched Chicago BigLaw SA positions. Obviously that is not going to apply to everyone, just some perspective.
Better 2L grades will also help more if you have to OCI as a 3L.
Obviously, easier classes does not always equal better grades. My A in a horrendous evidence class yet a B in my cake-walk of a professional responsibility speak volumes on that issue.
As an aside, I disagree with the Crim Pro comment. I think it is a very useful and interesting class (it's just a Con Law class exclusive to the 4th-5th-8th amendments) and one that can come in handy if you or your friends ever have a brush with the law.
I agree with the comments regarding getting your basic commercial law courses in before you venture into the more advanced classes.