No. Like RuskieGirl, I had lots of hours of AP and dual-enrollment credit in the bank, so I took only 110 hours at my degree-granting school, with only 7 in my final semester (special circumstances). My total number of credits is obviously way beyond what was required, though. This didn't keep me out anywhere, so far - I'm into several top 10 schools.
I do think it could hurt you more if your numbers are low, though, especially if you are sub-50th percentile in your class.
P.S. I recommend taking lots of interesting courses for fun - explore your options while in college.