If you want to go to a club, your best bet is the city. That really goes for anything even remotely resembling fun and entertainment. And even for that, SF is fairly deficient.
That's the first time I ever heard anyone say that SF is 'deficient' when it comes to entertainment. I lived there for a summer, & nothing could be further from the truth, I think.. let me guess, are you from NY or LA?
I'm actually from the South, and I mostly went out in Atlanta, Miami, the Tampa Bay Area and NYC (when I went up to visit my sister).
I should say that maybe "deficient" wasn't the most appropriate term to use. I simply find that SF lacks that "zing" that I felt on the east coast. Certainly, many people may and do feel otherwise.