I'd agree with a lot of the bands mentioned already, Arctic Monkeys, Wolf Parade, Wilco, CLYHSY,etc.
A few others I'd mention:
We Are Scientists-With Love and Squalor
Belle and Sebastian-The Life Pursuit
Jenny Lewis and the Watson Twins-Rabbit Fur Coat
The Hold Steady-Separation Sunday (not brand new, came out last year)
The New Pornographers-Twin Cinema
Okkervil River-Black Sheep Boy
Ted Leo and the Pharmacists-Shake the Sheets
yes. We Are Scientists toured with a band called Speechwriters LLC for a bit. SWLL haven't broken yet, but I fully expect them to in the near future.
Also: CBGB--its a shame about your namesake.
A friend of mine saw We Are Scientists a few weeks ago in Toronto, unfortunately they didn't make the trip up here to Ottawa. He said it was the best show from a new band that he could remember, and this is from a guy who goes to a lot of shows. They show a lot of potential, and write catchy songs. I thought a lot of the reviews were kind of unfair to them, but that's how it goes I guess.
As for CBGB's, what's the latest? I'd heard it had basically been run into the ground, and was pretty much a dump these days. It's not completely gone is it? Visiting that place is one of my life goals (sad as that may be).